Topic
MODY Subtypes & What They Mean
How the common MODY subtypes differ, and why treatment depends on which one it is.
The Common Subtypes
Three genes account for the large majority of all identified MODY, and they behave quite differently. Here they are, set out clearly side by side.
GCK-MODY: Mild, Stable, Untreated
GCK-MODY resets your glucose thermostat slightly higher. Treatment is generally ineffective here, and complications are strikingly uncommon.
HNF1A-MODY: The Responsive One
HNF1A is the commonest MODY subtype in Indians, it progresses over time, and it responds strikingly well to low doses of one very old tablet.
HNF4A-MODY and Its Newborn Twist
HNF4A behaves much like HNF1A does in adults, and does something distinctive at birth — a large baby with low blood sugar in the first days.
Rarer Subtypes: HNF1B and Others
Some monogenic diabetes affects organs beyond the pancreas. HNF1B is the clearest example, and it changes what needs to be monitored here.